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529659 Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem

A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background with equal or higher potency than Y-27632.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: DDD00033325

529659
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1259034-82-6C₁₇H₁₉N₅

Products

RéférenceConditionnement Qté
529659-10MG Flacon en verre 10 mg
Description
OverviewA cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
Catalogue Number529659
Brand Family Calbiochem®
SynonymsDDD00033325
References
ReferencesAndrews, P.D., et al. 2010. Biochem. J. 432, 21.
Product Information
CAS number1259034-82-6
FormYellow syrup
Hill FormulaC₁₇H₁₉N₅
Chemical formulaC₁₇H₁₉N₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
529659-10MG 04055977269307

Documentation

Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Pro-survival Compound, DDD00033325 - CAS 1259034-82-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
529659

Références bibliographiques

Aperçu de la référence bibliographique
Andrews, P.D., et al. 2010. Biochem. J. 432, 21.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2012 JSW
SynonymsDDD00033325
DescriptionA cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (>83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
FormYellow syrup
Intert gas (Yes/No) Packaged under inert gas
CAS number1259034-82-6
Chemical formulaC₁₇H₁₉N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesAndrews, P.D., et al. 2010. Biochem. J. 432, 21.