Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

530070 Pristimerin - CAS 1258-84-0 - Calbiochem

A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii.

Pristimerin - CAS 1258-84-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Monoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX, MAGL Inhibitor II

530070
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1258-84-0C₃₀H₄₀O₄

Products

RéférenceConditionnement Qté
530070-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50 = 2.2 and 3.0 µM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC50 ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50 = 93 nM).
Catalogue Number530070
Brand Family Calbiochem®
SynonymsMonoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX, MAGL Inhibitor II
References
ReferencesLu, Z., et al. 2010. Mol. Cancer 9, 112.
King, A.R., et al. 2009. Chem. Biol. 16, 1045.
Tiedemann, R.E., et al. 2009. Blood 113, 4027.
Yang, H., et al. 2008. J. Cell. Biochem. 103, 234.
Wu, C.C., et al. 2005. Mol. Cancer Ther. 4, 1277.
Product Information
CAS number1258-84-0
FormRed solid
Hill FormulaC₃₀H₄₀O₄
Chemical formulaC₃₀H₄₀O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 20-24/25-36/37/39

When using do not eat or drink.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
530070-5MG 04055977269352

Documentation

Pristimerin - CAS 1258-84-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Pristimerin - CAS 1258-84-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
530070

Références bibliographiques

Aperçu de la référence bibliographique
Lu, Z., et al. 2010. Mol. Cancer 9, 112.
King, A.R., et al. 2009. Chem. Biol. 16, 1045.
Tiedemann, R.E., et al. 2009. Blood 113, 4027.
Yang, H., et al. 2008. J. Cell. Biochem. 103, 234.
Wu, C.C., et al. 2005. Mol. Cancer Ther. 4, 1277.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-August-2010 RFH
SynonymsMonoacylglycerol Lipase Inhibitor II, Proteasome Inhibitor XV, NF-κB Activation Inhibitor IX, MAGL Inhibitor II
DescriptionA cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC50 = 2.2 and 3.0 µM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC50 ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC50 = 93 nM).
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1258-84-0
Chemical formulaC₃₀H₄₀O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (2.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLu, Z., et al. 2010. Mol. Cancer 9, 112.
King, A.R., et al. 2009. Chem. Biol. 16, 1045.
Tiedemann, R.E., et al. 2009. Blood 113, 4027.
Yang, H., et al. 2008. J. Cell. Biochem. 103, 234.
Wu, C.C., et al. 2005. Mol. Cancer Ther. 4, 1277.