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516481 Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem

Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid

Primary Target: cathepsin D
516481
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
26305-03-3C₃₄H₆₃N₅O₉

Products

RéférenceConditionnement Qté
516481-100MG Ampoule plast. 100 mg
516481-25MG Ampoule plast. 25 mg
516481-5MG Ampoule plast. 5 mg
Description
OverviewA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
Effective concentration: 1.0 µM.
Catalogue Number516481
Brand Family Calbiochem®
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
References
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.
Product Information
CAS number26305-03-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₄H₆₃N₅O₉
Chemical formulaC₃₄H₆₃N₅O₉
Optical rotationOptical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin D
Primary Target IC<sub>50</sub>EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSC6155000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
516481-100MG 04055977198812
516481-25MG 07790788055837
516481-5MG 04055977198836

Documentation

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
516481

Références bibliographiques

Aperçu de la référence bibliographique
Isahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.

Brochure

Titre
Western Blotting Tools

Informations techniques

Titre
Protein Blotting Handbook: 6th Edition
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-October-2013 JSW
SynonymsIva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
DescriptionA reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
FormWhite solid
Recommended reaction conditions
Activity:
Activity is measured by inhibition of pepsin. 1 U corresponds to the amount of inhibitor that reduces the activity of pepsin by 1 U (1 U of enzyme corresponds to the amount of enzyme that results in the increases the absorbance at 280 nm by 0.001 per min at pH 2.0, 37°C.)
CAS number26305-03-3
RTECSSC6155000
Chemical formulaC₃₄H₆₃N₅O₉
Purity≥98% by HPLC
SolubilityDMSO (1 mg/ml) or Methanol (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 7147
ReferencesIsahara, K., et al. 1999. Neuroscience 91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233.
Carraway, R.E., et al. 1991. Peptides 12, 107.
Eid, M., et al. 1981. Biochem. J. 197, 465.
Umezawa, H., et al. 1970. J. Antibiot. 23, 259.