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537983 Pantothenate Kinase Inhibitor - Calbiochem

Cell-permeable, potent and reversible PanK inhibitor. Blocks de novo CoA biosynthesis (IC₅₀ = 0.9 µM in C3A cells).

Pantothenate Kinase Inhibitor - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor

537983
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Aperçu

Replacement Information

Products

RéférenceConditionnement Qté
5379830001 Flacon en verre 10 mg
Description
OverviewA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number537983
Brand Family Calbiochem®
Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
DescriptionPantothenate Kinase Inhibitor
References
ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
Product Information
FormOrange solid
Hill FormulaC₂₁H₂₁N₅O
Chemical formulaC₂₁H₂₁N₅O
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetpantothenate kinase
Primary Target IC<sub>50</sub>70, 92 and 25 nM for PanK1&beta
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5379830001 04054839133381

Documentation

Pantothenate Kinase Inhibitor - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Sharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-September-2016 JSW
Synonyms3-(2,4-Dimethylpyrido-[2ʹ,3ʹ:3,4]pyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-(methylthio)phenyl)propanamide, PanK Inhibitor
DescriptionA cell-permeable pyridopyrazolopyrimidine based compound that acts as a potent and reversible inhibitor of pantothenate kinase (IC50 = 70, 92 and 25 nM for PanK1β, PanK2 and PanK3, respectively; radiochemical assay, 2.5 mM [ATP]). Binds to ATP-PanK complex (apparent binding constant ~300 nM for ATP-PanK3) and exhibits mixed-type inhibition with respect to ATP and pantothenate. Shown to dose-dependently decrease [3H]pantothenate incorporation into coenzyme A (apparent IC50 = 900 nM in C3A cells) with negligible off-target toxicity (IC50 > 56 µM in Hep-G2 cells).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₁H₂₁N₅O
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSharma, L.K., et al. 2015. J. Med. Chem. 58, 1563.