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528116 PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem

The PI 3-Kα Inhibitor VIII controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII

528116
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
372196-77-5C₁₆H₁₄N₅O₄SBr • HCl • 2H₂O

Products

RéférenceConditionnement Qté
528116-5MG Plastic Bag(s) 5 mg
Description
OverviewA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
Catalogue Number528116
Brand Family Calbiochem®
SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
References
ReferencesKim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.
Product Information
CAS number372196-77-5
FormPale yellow solid
Hill FormulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
528116-5MG 04055977196993

Documentation

PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

PI 3-Kα Inhibitor VIII - CAS 372196-77-5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
528116

Références bibliographiques

Aperçu de la référence bibliographique
Kim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.

Posters

Titre
Human Kinome & InhibitorSelect™ Libraries
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-December-2013 JSW
SynonymsN-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-Nʹ-methyl-Nʹʹ-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
DescriptionA cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number372196-77-5
Chemical formulaC₁₆H₁₄N₅O₄SBr • HCl • 2H₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesKim, S., et al. 2007. Blood 110, 4206.
Hayakawa, M., et al. 2007. Bioorg. Med. Chem. 15, 5837.
Knight, Z.A., et al. 2007. Cell 125, 733.