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524748 PDE4D Inhibitor, GEBR-7b - CAS 1349848-90-3 - Calbiochem

The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime

524748
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1349848-90-3C₂₁H₃₀N₂O₅

Products

RéférenceConditionnement Qté
524748-5MG Flacon en verre 5 mg
Description
OverviewA cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
Catalogue Number524748
Brand Family Calbiochem®
SynonymsGEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
References
ReferencesBruno, O., et al. 2011. Br. J. Pharmacol. in press.
Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.
Product Information
CAS number1349848-90-3
FormPale yellow semi-solid
Hill FormulaC₂₁H₃₀N₂O₅
Chemical formulaC₂₁H₃₀N₂O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
524748-5MG 04055977197075

Documentation

PDE4D Inhibitor, GEBR-7b - CAS 1349848-90-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

PDE4D Inhibitor, GEBR-7b - CAS 1349848-90-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
524748

Références bibliographiques

Aperçu de la référence bibliographique
Bruno, O., et al. 2011. Br. J. Pharmacol. in press.
Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2012 JSW
SynonymsGEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
DescriptionA cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
FormPale yellow semi-solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1349848-90-3
Chemical formulaC₂₁H₃₀N₂O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml; clear, colorless solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBruno, O., et al. 2011. Br. J. Pharmacol. in press.
Bruno, O., et al. 2009. J. Med. Chem. 52, 6546.