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513040 PD 174265 - CAS 216163-53-0 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 450 pM).

PD 174265 - CAS 216163-53-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline

Primary Target: EGFR tyrosine kinase activity
513040
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
216163-53-0C₁₇H₁₅BrN₄O

Products

RéférenceConditionnement Qté
513040-1MG Ampoule plast. 1 mg
Description
OverviewA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
Catalogue Number513040
Brand Family Calbiochem®
Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
References
ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
Product Information
CAS number216163-53-0
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₇H₁₅BrN₄O
Chemical formulaC₁₇H₁₅BrN₄O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEGFR tyrosine kinase activity
Primary Target IC<sub>50</sub>450 pM against EGF receptor (EGFR) tyrosine kinase activity
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
513040-1MG 04055977198669

Documentation

PD 174265 - CAS 216163-53-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

PD 174265 - CAS 216163-53-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
513040

Références bibliographiques

Aperçu de la référence bibliographique
Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-February-2012 RFH
Synonyms4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
DescriptionA potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.45 nM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number216163-53-0
Chemical formulaC₁₇H₁₅BrN₄O
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.