234490 Sigma-AldrichPD 153035 - CAS 153436-54-5 - Calbiochem
An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM).
More>> An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC₅₀ = 25 pM; Ki = 6 pM). Less<<PD 153035 - CAS 153436-54-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 153436-54-5 | C₁₆H₁₄BrN₃O₂ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 234490-1MG | Ampoule plast. | 1 mg |
| Description | |
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| Overview | An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available. |
| Catalogue Number | 234490 |
| Brand Family | Calbiochem® |
| Synonyms | AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32 |
| References | |
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| References | Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093. |
| Product Information | |
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| CAS number | 153436-54-5 |
| ATP Competitive | Y |
| Declaration | Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266. |
| Form | White solid |
| Hill Formula | C₁₆H₁₄BrN₃O₂ |
| Chemical formula | C₁₆H₁₄BrN₃O₂ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | EGFR |
| Primary Target IC<sub>50</sub> | 25 pM |
| Primary Target K<sub>i</sub> | 6 pM against epidermal growth factor receptor (EGFR) |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 234490-1MG | 04055977200256 |
Documentation
PD 153035 - CAS 153436-54-5 - Calbiochem FDS
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PD 153035 - CAS 153436-54-5 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 234490 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267. Fry, D.W., et al. 1994. Science 265, 1093. |
Brochure
| Titre |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
Informations techniques
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| JAK/STAT Signaling Research Focus |
Posters
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| Human Kinome & InhibitorSelect™ Libraries |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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