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513022 PD 150606 - CAS 426821-41-2 - Calbiochem

A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2.

PD 150606 - CAS 426821-41-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid

Primary Target: Calpain-1
513022
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
426821-41-2C₉H₇IO₂S

Products

RéférenceConditionnement Qté
513022-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 (Cat. Nos. 208712 and 208713) and 370 nM for calpain-2 (Cat. Nos. 208715 and 208718)] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
Catalogue Number513022
Brand Family Calbiochem®
Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
References
ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
Product Information
CAS number426821-41-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₉H₇IO₂S
Chemical formulaC₉H₇IO₂S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalpain-1
Primary Target K<sub>i</sub>210 nM for calpain-1 and 370 nM for calpain-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
513022-5MG 04055977198591

Documentation

PD 150606 - CAS 426821-41-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

PD 150606 - CAS 426821-41-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
513022

Références bibliographiques

Aperçu de la référence bibliographique
Lin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.

Citations

Titre
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•
    Fiche technique

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision15-April-2011 RFH
    Synonyms3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic Acid
    DescriptionA cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes.
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number426821-41-2
    Chemical formulaC₉H₇IO₂S
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    Toxicity Standard Handling
    ReferencesLin, G.D., et al. 1997. Nat. Struct. Biol. 4, 539.
    Squier, M.K., and Cohen, J.J. 1997. J. Immunol. 158, 3960.
    Edelstein, C.L., et al. 1996. Kidney Int. 50, 1150.
    Wang, K.K.W., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687.
    Citation
  • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
    		•