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480060 Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem

The Necrosis Inhibitor, IM-54, also referenced under CAS 861891-50-1, selectively blocks oxidative stress-induced necrotic cell death. This small molecule/inhibitor is primarily used for Cancer applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(1H-Indol-3-yl)-3-pentylamino-maleimide

Primary Target: Blocks oxidative stress-induced necrotic cell death
480060
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
861891-50-1C₁₉H₂₃N₃O₂

Products

RéférenceConditionnement Qté
480060-5MG Flacon en verre 5 mg
Description
OverviewA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
Catalogue Number480060
Brand Family Calbiochem®
Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
References
ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
Product Information
CAS number861891-50-1
ATP CompetitiveN
FormYellow orange solid
Hill FormulaC₁₉H₂₃N₃O₂
Chemical formulaC₁₉H₂₃N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBlocks oxidative stress-induced necrotic cell death
Primary Target IC<sub>50</sub>(~3 µM prevented ~50% cell death in HL60 cells exposed to 100 µM H₂O₂).
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
480060-5MG 04055977201864

Documentation

Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Necrosis Inhibitor, IM-54 - CAS 861891-50-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
480060

Références bibliographiques

Aperçu de la référence bibliographique
Dodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms2-(1H-Indol-3-yl)-3-pentylamino-maleimide
DescriptionA cell-permeable mono-indolylmaleimide compound that selectively blocks oxidative stress-induced necrotic cell death (~3 µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100 µM H2O2). Does not offer protection against Etoposide- (Cat. No. 341205) induced apoptosis or display antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as high as 50 µM.
FormYellow orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number861891-50-1
Chemical formulaC₁₉H₂₃N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesDodo, K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3114.