480403 Sigma-AldrichNFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem
The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Inhibitor of NFAT-Calcineurin Association-6, INCA-6
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 3519-82-2 | C₂₀H₁₂O₂ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 480403-5MG | Ampoule plast. | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable quinone compound that acts as a potent and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT and completely blocks its dephosphorylation, nuclear import of NFAT (~40 µM in C1.7W2 T cells), and induction of cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling. |
| Catalogue Number | 480403 |
| Brand Family | Calbiochem® |
| Synonyms | Inhibitor of NFAT-Calcineurin Association-6, INCA-6 |
| References | |
|---|---|
| References | Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554. |
| Product Information | |
|---|---|
| CAS number | 3519-82-2 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₂₀H₁₂O₂ |
| Chemical formula | C₂₀H₁₂O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Primary Target | Calcineurin-NFAT |
| Primary Target IC<sub>50</sub> | Kd = 800 nM for calcineurin-NFAT |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information |
|---|
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 480403-5MG | 04055977201321 |
Documentation
NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem FDS
| Titre |
|---|
NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 480403 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Roehrl, M.H.A., et al. 2004. Biochemistry 43, 16067. Roehrl, M.H.A., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 7554. |