481406 Sigma-AldrichNF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem
The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 545380-34-5 | C₂₂H₂₀N₄O |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 481406-1MG | Plastic Bag(s) | 1 mg |
| Description | |
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| Overview | A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available. |
| Catalogue Number | 481406 |
| Brand Family | Calbiochem® |
| Synonyms | 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline |
| References | |
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| References | Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383. |
| Product Information | |
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| CAS number | 545380-34-5 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₂₂H₂₀N₄O |
| Chemical formula | C₂₂H₂₀N₄O |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NF-κB transcriptional activation |
| Primary Target IC<sub>50</sub> | 11 nM against NF-κB transcriptional activation in Jurkat cells |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 481406-1MG | 04055977201505 |
Documentation
NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem FDS
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NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 481406 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383. |