480026 Sigma-AldrichNBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem
A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀~ 50 µM in HCT116 cells).
More>> A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀~ 50 µM in HCT116 cells). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
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Aperçu
| Replacement Information |
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Tableau de caractéristiques principal
| Empirical Formula |
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| C₁₂₃H₁₉₇N₄₇O₃₂ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 480026-5MG | Flacon en verre | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025). |
| Catalogue Number | 480026 |
| Brand Family | Calbiochem® |
| Synonyms | NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD |
| References | |
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| References | Hong, S., et al. 2012. Mol. Pharm. 9, 1310. Kim, D., et al. 2006. Exp. Cell Res. 312, 1277. |
| Product Information | |
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| Form | White solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₂₃H₁₉₇N₄₇O₃₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Sold on the basis of peptide content | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NEMO-binding peptide |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Content | Y |
| Peptide Sequence | Ac-YGRRARRRARRTALDWSWLQTE-NH₂ |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 480026-5MG | 04055977201840 |
Documentation
NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem FDS
| Titre |
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NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 480026 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Hong, S., et al. 2012. Mol. Pharm. 9, 1310. Kim, D., et al. 2006. Exp. Cell Res. 312, 1277. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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