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475951 MreB Perturbing Compound A22 - CAS 22816-60-0 - Calbiochem

A cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: S-(3,4-Dichlorobenzyl)isothiourea, HCl

Primary Target: MreB
475951
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Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
22816-60-0C₈H₈Cl₂N₂S • HCl

Products

RéférenceConditionnement Qté
475951-25MG Ampoule plast. 25 mg
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Description
OverviewA cell-permeable isothiourea compound that specifically, rapidly and reversibly perturbs MreB function without affecting eukaryotic actin polymerization. Reported to affect the growth and morphology of Caulobacter crescentus, convert rod-shaped E. coli to round cells, and block DNA segregation without affecting DNA replication. Suggested to interact with MreB's nucleotide binding pocket and is useful for the temporal analysis of MreB function.
Catalogue Number475951
Brand Family Calbiochem®
SynonymsS-(3,4-Dichlorobenzyl)isothiourea, HCl
References
ReferencesGitai, Z., et al. 2005. Cell 120, 329.
Jensen, R.B., et al. 2002. Nat. Rev. Mol. Cell Biol. 3, 167.
Iwai, N., et al. 2002. Biosci. Biotechnol. Biochem. 66, 2658.
Product Information
CAS number22816-60-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₈H₈Cl₂N₂S • HCl
Chemical formulaC₈H₈Cl₂N₂S • HCl
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMreB
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C. DMSO stock solutions are stable for up to 1 month at -20°C. Reconstitute in H₂O just prior to use; aqueous stock solutions are stable for up to 12 hr. Stable for up to 2 days in acidic medium.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
475951-25MG 07790788050580