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475879 Monastrol - CAS 254753-54-3 - Calbiochem

A potent, cell-permeable, non-tubulin-interacting mitosis inhibitor.

Monastrol - CAS 254753-54-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I

Primary Target: Mitotic kinesin Eg5
475879
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
254753-54-3C₁₄H₁₆N₂O₃S

Products

RéférenceConditionnement Qté
475879-1MG Ampoule plast. 1 mg
475879-5MG Ampoule plast. 5 mg
Description
OverviewA potent, cell-permeable, non-tubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
Catalogue Number475879
Brand Family Calbiochem®
Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
References
ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.
Product Information
CAS number254753-54-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₄H₁₆N₂O₃S
Chemical formulaC₁₄H₁₆N₂O₃S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMitotic kinesin Eg5
Primary Target IC<sub>50</sub>14 µM against mitotic kinesin Eg5
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
475879-1MG 04055977203479
475879-5MG 04055977203486

Documentation

Monastrol - CAS 254753-54-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Monastrol - CAS 254753-54-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
475879

Références bibliographiques

Aperçu de la référence bibliographique
Kapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2008 RFH
Synonyms4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic Acid Ethyl Ester, Eg5 Inhibitor I
DescriptionA potent, cell-permeable, nontubulin-interacting mitosis inhibitor. Arrests mammalian cells in mitosis with monopolar spindles. In vitro, it specifically inhibits the motility of the mitotic kinesin Eg5, a motor protein involved in the assembly and maintenance of the mitotic spindle (IC50 = 14 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number254753-54-3
Chemical formulaC₁₄H₁₆N₂O₃S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKapoor, T.M., et al. 2000. J. Cell Biol. 150, 975.
Mayer, T.U., et al. 1999. Science 286, 971.