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FCMAB385F Milli-Mark™ Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1

Milli-Mark Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1 detects level of GRK 2/3 (βARK 1/2) & has been published & validated for use in FC.

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Research Category: Signaling Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: ADRBK1, Beta-ARK-1, GRK2, BARK, FLJ16718 UniProt Number: P26817
FCMAB385F
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Tableau de caractéristiques principal

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB385F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1
Alternate Names
  • G-protein coupled receptor kinase 2
  • adrenergic, beta, receptor kinase 1
  • beta adrenergic receptor kinase 1
Background InformationThe beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the ADRBK2 enzyme, also known as GRK3, has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
GRK2 phosphorylates the beta2 adrenergic receptor. It is a ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors.
References
Product Information
FormatFITC
Control
  • HeLa cells
PresentationPurified mouse monoclonal IgG2aκ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Applications
ApplicationMilli-Mark Anti-GRK 2/3 (βARK 1/2)-FITC Antibody, clone C5/1.1 detects level of GRK 2/3 (βARK 1/2) & has been published & validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
Immunogen Partial GST fusion protein corresponding to rat GRK3 (βARK2) at the carboxyl terminus.
Epitopecarboxyl terminus
CloneC5/1.1
HostMouse
SpecificityAntibody recognizes GRK 2/3.
IsotypeIgG2aκ
Species Reactivity
  • Human
Species Reactivity NoteTested and passed on human. Predicted to react with Rat based on immunogen design.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • ADRBK1
  • Beta-ARK-1
  • GRK2
  • BARK
  • FLJ16718
Purification MethodProtein G Purified
UniProt Number
UniProt SummarySpecifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them.
Molecular Weight80 kDa Calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
FCMAB385F 0