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506419 Methysergide Maleate - CAS 129-49-7 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491

Primary Target: 5-HT
506419
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
129-49-7C₂₁H₂₇N₃O₂·C₄H₄O₄

Products

RéférenceConditionnement Qté
5064190001 Flacon en verre 10 mg
Description
OverviewAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
Catalogue Number506419
Brand Family Calbiochem®
Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
References
ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
IUHPAR Database 2013.
Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
Product Information
CAS number129-49-7
FormOff-white solid
Hill FormulaC₂₁H₂₇N₃O₂·C₄H₄O₄
Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-HT
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 25

Toxic if swallowed.
S PhraseS: 36/37/39-46

Wear suitable protective clothing, gloves and eye/face protection.
If swallowed, seek medical advice immediately and show this container or label.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5064190001 04055977242737

Documentation

Methysergide Maleate - CAS 129-49-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Matsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
IUHPAR Database 2013.
Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-October-2013 JSW
Synonyms5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
DescriptionAn antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
FormOff-white solid
CAS number129-49-7
Chemical formulaC₂₁H₂₇N₃O₂·C₄H₄O₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (10 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesMatsuta, Y. et al. 2013. Exp. Neurol. 247, 250.
IUHPAR Database 2013.
Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res. 183, 411.
Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370, 114.
Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther. 277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol. 58, 505.