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14-695M MST3 Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304, for use in Kinase Assays.

14-695M
250 µg  Also available in 10 μg size (cat#14-695) and in bulk (cat#14-695-K).
Purchase on Sigma-Aldrich

Aperçu

Replacement Information
Description
Catalogue Number14-695M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionMST3 Protein, active, 250 µg
OverviewN-terminal GST-tagged, recombinant, human MST3, amino acids 1-304
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryThe yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM]
Gene Symbol
  • STK24
  • MST3B
  • MST3
  • MST-3
  • STK3
Protein TargetMST3
Purification MethodGlutathione agarose affinity chromatography
Target Sub-FamilySTE
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9Y6E0 # Protein kinase that act on both serine and threonine residues.
COFACTOR: Manganese. Only isoform A requires manganese.
SIZE: 443 amino acids; 49308 Da
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
PTM: Autophosphorylated. Isoform B is activated by phosphorylation by PKA.
SIMILARITY: SwissProt: Q9Y6E0 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
Molecular Weight61.2kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of PKCtide (Catalog# 12-536)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditionsstable for 6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-695) and in bulk (cat#14-695-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
14-695M 04053252925368

Documentation

Produits & Applications associés

Alternative Packsize

Référence Description
14-695 MST3 Protein, active, 10 µg

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Catégories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases