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444252 MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem

444252
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Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
204140-01-2C₂₅H₂₅N₃O₆S

Products

RéférenceConditionnement Qté
444252-1MG Ampoule plast. 1 mg
Description
OverviewA piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC50 = 900 pM) and MMP-13 (IC50 = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC50 = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC50 = 930 nM).
Catalogue Number444252
Brand Family Calbiochem®
SynonymsN-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
References
ReferencesCheng, M., et al. 2000. J. Med. Chem. 43, 369.
Product Information
CAS number204140-01-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₅H₂₅N₃O₆S
Chemical formulaC₂₅H₂₅N₃O₆S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMMP-9
Primary Target IC<sub>50</sub>900 pM against both MMP-9 and MMP-13
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
444252-1MG 04055977186529