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444249 MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem

The MMP-2/MMP-9 Inhibitor II, also referenced under CAS 193807-60-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS

Primary Target: MMP-2
444249
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
193807-60-2C₂₁H₂₀N₂O₄S

Products

RéférenceConditionnement Qté
444249-1MG Ampoule plast. 1 mg
Description
OverviewA potent inhibitor of MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Reported to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
Catalogue Number444249
Brand Family Calbiochem®
Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
References
ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
Product Information
CAS number193807-60-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₀N₂O₄S
Chemical formulaC₂₁H₂₀N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2
Primary Target IC<sub>50</sub>17 nM, 30 nM against MMP-2, and MMP-9, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
444249-1MG 04055977186499

Documentation

MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

MMP-2/MMP-9 Inhibitor II - CAS 193807-60-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
444249

Références bibliographiques

Aperçu de la référence bibliographique
Lauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2011 RFH
Synonyms(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide, BiPS, BiPS
DescriptionA potent inhibitor of type IV collagenases, MMP-2 (IC50 = 17 nM) and MMP-9 (IC50 = 30 nM). Also shown to potently induce and rapidly activate HIF. Has been shown in vivo to inhibit Lewis lung carcinoma-induced lung colonization in a murine model.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number193807-60-2
Chemical formulaC₂₁H₂₀N₂O₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (25 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLauzier, M.C., et al. 2008. Mol. Pharmacol. In press.
Mifune, M., et al. 2005. J. Biol. Chem. 280, 26592.
Zhang, H., et al. 2004. Circ. Res. 95, 989.
Tamura, Y., et al. 1998. J. Med. Chem. 41, 640.