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444284 MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

444284
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
199850-67-4C₁₇H₁₈BrNO₄S

Products

RéférenceConditionnement Qté
444284-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Catalogue Number444284
Brand Family Calbiochem®
Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
References
ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
Product Information
CAS number199850-67-4
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₇H₁₈BrNO₄S
Chemical formulaC₁₇H₁₈BrNO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2, -3, and -13
Primary Target IC<sub>50</sub>47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
444284-5MG 04055977186017

Documentation

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem Certificats d'analyse

TitreNuméro de lot
444284

Références bibliographiques

Aperçu de la référence bibliographique
Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2008 RFH
Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
DescriptionA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
FormOff-white solid
CAS number199850-67-4
Chemical formulaC₁₇H₁₈BrNO₄S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (40 mg/ml) or Ethanol (40 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.