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474790 MG-132 - CAS 133407-82-6 - Calbiochem

474790
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Tableau de caractéristiques principal

CAS #Empirical Formula
133407-82-6C₂₆H₄₁N₃O₅

Products

RéférenceConditionnement Qté
474790-10MG Ampoule plast. 10 mg
474790-1MG Ampoule plast. 1 mg
474790-20MG 20 mg
474790-5MG Ampoule plast. 5 mg
Description
OverviewA potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available.
Catalogue Number474790
Brand Family Calbiochem®
SynonymsCarbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
References
ReferencesLi, Z.W. et al. 2011. Sheng Li Xue Bao. 63, 525.
Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.
Product Information
CAS number133407-82-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₄₁N₃O₅
Chemical formulaC₂₆H₄₁N₃O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetproteasome
Primary Target IC<sub>50</sub>3 µM against NF-κB activation
Primary Target K<sub>i</sub>4 nM against proteasome
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Leu-Leu-CHO
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Global Trade Item Number
Référence GTIN
474790-10MG 04055977185485
474790-1MG 07790788050436
474790-20MG 04055977185492
474790-5MG 07790788050443