Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

437725 Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem

Lipoxin A₄, 15-epi, CAS 171030-11-8, is an epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: LXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid

437725
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
171030-11-8C₂₀H₃₂O₅

Products

RéférenceConditionnement Qté
437725-25UG Flacon en verre 25 μg
Description
OverviewA epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Blocks TNF-α-induced IL-8 release in human enterocyte. It is also an important modulator of the many pharmacological actions caused by aspirin.
Caution! Product contains volatile liquid. Keep product cold at all times.
Catalogue Number437725
Brand Family Calbiochem®
SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
References
ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
Claria, J., et al. 1996. Mol. Med. 2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
Product Information
CAS number171030-11-8
ATP CompetitiveN
FormLiquid
FormulationIn Ethanol.
Hill FormulaC₂₀H₃₂O₅
Chemical formulaC₂₀H₃₂O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetExhibits anti-inflammatory properties
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
437725-25UG 04055977186895

Documentation

Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Lipoxin A₄, 15-epi - CAS 171030-11-8 - Calbiochem Certificats d'analyse

TitreNuméro de lot
437725

Références bibliographiques

Aperçu de la référence bibliographique
Wallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
Claria, J., et al. 1996. Mol. Med. 2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
Serhan, C.N., et al. 1995. Biochemistry 34, 14609.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-August-2008 RFH
SynonymsLXA₄-15-epi, 15(R)-LXA₄, Aspirin-triggered LXA₄, (5S,6R,15R)-5,6,15-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid
DescriptionAn epimeric lipoxin A4 (Cat. No. 437720) analog that is more potent and metabolically stable than LXA4. Exhibits anti-inflammatory properties and serves as a "stop signal" to excessive leukocyte trafficking/infiltration. Reported to block TNF-α-induced IL-8 release in human enterocytes. Also reported to be an important modulator of the pharmacological actions of aspirin.

Caution! Product contains volatile liquid; keep cold at all times.
FormLiquid
FormulationIn Ethanol.
Intert gas (Yes/No) Packaged under inert gas
CAS number171030-11-8
Chemical formulaC₂₀H₃₂O₅
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw aliquot and freeze (-70°C).
Toxicity Flammable
ReferencesWallace, J.L., and Fiorucci, S. 2003. Trends Pharmacol. Sci. 24, 323.
Filep, J.G., et al. 2002. Adv. Exp. Med. Biol. 507, 223.
Titos, E., et al. 1999. Am. J. Physiol. 277, C870.
Gronert, K., et al. 1998. J. Exp. Med. 187, 1285.
Maddox, J.F., et al. 1997. J. Biol. Chem. 272, 6972.
Claria, J., et al. 1996. Mol. Med. 2, 583.
Claria, J., and Serhan, C.N. 1995. Proc. Natl. Acad. Sci. USA 92, 9475.
Serhan, C.N., et al. 1995. Biochemistry 34, 14609.