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420135 JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem

JNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide

420135
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Aperçu

Replacement Information

Products

RéférenceConditionnement Qté
420135-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
Catalogue Number420135
Brand Family Calbiochem®
SynonymsN-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
References
ReferencesVivanco, I., et al. 2007. Cancer Cell 11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
Product Information
CAS number894804-07-0
ATP CompetitiveY
FormBrown solid
Hill FormulaC₁₈H₂₀N₄O₄
Chemical formulaC₁₈H₂₀N₄O₄
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationJNK Inhibitor VIII, CAS 894804-07-0, is a cell-permeable, ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively).
Biological Information
Primary TargetJNK
Primary Target K<sub>i</sub>2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
420135-5MG 04055977187656

Documentation

JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

JNK Inhibitor VIII - CAS 894804-07-0 - Calbiochem Certificats d'analyse

TitreNuméro de lot
420135

Références bibliographiques

Aperçu de la référence bibliographique
Vivanco, I., et al. 2007. Cancer Cell 11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2008 RFH
SynonymsN-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide
DescriptionA cell-permeable pyridinylamide compound that acts as an ATP-competitive, reversible inhibitor of JNK (Ki = 2 nM, 4 nM and 52 nM for JNK1, 2 and 3, respectively) and displays excellent selectivity over 72 other kinases. Inhibits c-jun phosphorylation with an EC50 of 920 nM in HepG2 cells. Preferentially blocks the growth of PTEN null mouse embryonic fibroblasts.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number894804-07-0
Chemical formulaC₁₈H₂₀N₄O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesVivanco, I., et al. 2007. Cancer Cell 11, 555.
Szczepankiewicz, B. G., et al. 2006. J. Med. Chem. 49, 3563.