Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

420202 JMJD Histone Demethylase Inhibitor III - CAS 1310809-17-6 - Calbiochem

The JMJD Histone Demethylase Inhibitor III controls the biological activity of JMJD Histone Demethylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Histone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, JHDM Inhibitor III

420202
Purchase on Sigma-Aldrich

Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
1310809-17-6C₂₇H₂₉N₃O₆

Products

RéférenceConditionnement Qté
420202-5MG Flacon en verre 5 mg
Ajouter aux favoris
Description
OverviewA substrate (methyl lysine) and cofactor (α-ketoglutarate) mimicking bivalent benzylamino-butylamino-N-hydroxybutenoic acid compound that acts as a selective in vitro inhibitor of Jumonji domain-containing histone demethylases (JHDMs; IC50 = 4.3, 3.4, 5.9, 10 and 43 µM for JMJD2A, JMJD2C, JMJD2E, PHF8 and JMJD3, respectively) over LSD1, asparaginyl and prolyl hydroxylases, and histone deacetylases (IC50 = 54, 83, 31, 22, 620, 680 and >800 µM for PHD1, PHD2, PHD3, FIH, LSD1 and HDACs, respectively). The cellular active JHDM Inhibitor, Methylstat is also available (Cat. No. 420203).
Catalogue Number420202
Brand Family Calbiochem®
SynonymsHistone Lysine Demethylase Inhibitor X, (E)-4-(Hydroxy(4-(4-((naphthalen-1-ylcarbamoyloxy)methyl)benzylamino)butyl)amino)-4-oxobut-2-enoic acid, JHDM Inhibitor III
References
ReferencesLuo, X., et al. 2011. J. Am. Chem. Soc. 133, 9451.
Product Information
CAS number1310809-17-6
FormOff-white powder
Hill FormulaC₂₇H₂₉N₃O₆
Chemical formulaC₂₇H₂₉N₃O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
420202-5MG 04055977210767