420126 Sigma-AldrichJAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem
The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The JAK3 Inhibitor VI, also referenced under CAS 856436-16-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
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Aperçu
| Replacement Information |
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 856436-16-3 | C₁₈H₁₃N₃O • MeSO₃H |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 420126-5MG | Ampoule plast. | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable 3′-pyridyl oxindole compound that acts as a potent and reversible inhibitor of JAK3 (IC50 = 27 nM)and displays ~16-fold greater selectivity over JAK2. Binds to the enzyme active site and prevents IL-2-induced cellular phosphorylation of JAK3 and STAT5. Inhibits IL-2-induced cell proliferation (IC50 = 760 and 250 nM for mouse CTLL and human T-cells, respectively) and alleviates oxazolone-induced ear odema in mouse with an efficacy comparable to that of Dexamethasone (Cat. No. 265005). |
| Catalogue Number | 420126 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105. |
| Product Information | |
|---|---|
| CAS number | 856436-16-3 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₃N₃O • MeSO₃H |
| Chemical formula | C₁₈H₁₃N₃O • MeSO₃H |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | JAK-3 |
| Primary Target IC<sub>50</sub> | 27 nM |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 420126-5MG | 04055977188042 |
Documentation
JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem FDS
| Titre |
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JAK3 Inhibitor VI - CAS 856436-16-3 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 420126 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Chen, J., et al. 2006. Bioorg. Med. Chem. Lett. In press. Adams, C., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3105. |
Brochure
| Titre |
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| Pathways and Biomarkers of JAK/STAT Signaling |
Informations techniques
| Titre |
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| JAK/STAT Signaling Research Focus |