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420101 JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131

Primary Target: Janus family kinase 3
420101
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
202475-60-3C₁₆H₁₅N₃O₃

Products

RéférenceConditionnement Qté
420101-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
Catalogue Number420101
Brand Family Calbiochem®
Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
References
ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
Product Information
CAS number202475-60-3
ATP CompetitiveY
FormWhite to off-white solid
Hill FormulaC₁₆H₁₅N₃O₃
Chemical formulaC₁₆H₁₅N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJanus family kinase 3
Primary Target IC<sub>50</sub>78 µM against Janus family kinase 3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
420101-5MG 04055977187892

Documentation

JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
420101

Références bibliographiques

Aperçu de la référence bibliographique
Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

Informations techniques

Titre
JAK/STAT Signaling Research Focus
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
DescriptionA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number202475-60-3
Chemical formulaC₁₆H₁₅N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.