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508507 Isradipine - CAS 75695-93-1 - Calbiochem

A voltage gated calcium channel gating inhibitor of the dihydropyridine class.

Isradipine - CAS 75695-93-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110

Primary Target: CaV
508507
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
75695-93-1C₁₉H₂₁N₃O₅

Products

RéférenceConditionnement Qté
5085070001 Flacon en verre 10 mg
Description
OverviewA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508507
Brand Family Calbiochem®
SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
References
ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
Product Information
CAS number75695-93-1
FormYellow solid
Hill FormulaC₁₉H₂₁N₃O₅
Chemical formulaC₁₉H₂₁N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCaV
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5085070001 04055977262001

Documentation

Isradipine - CAS 75695-93-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Chan, C. S. et al. 2007. Nature. 447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
Koschak, A. et al. 2001. J. Biol Chem 276, 22100.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-January-2014 JSW
SynonymsL-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
DescriptionA water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC50 of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.
FormYellow solid
CAS number75695-93-1
Chemical formulaC₁₉H₂₁N₃O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM) or Ethanol (50 mM)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChan, C. S. et al. 2007. Nature. 447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci. 45, 708.
Koschak, A. et al. 2003. J. Neurosci./i> 23, 6041.
Koschak, A. et al. 2001. J. Biol Chem 276, 22100.