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584223 InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem

584223
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
18771-50-1C₉H₁₆N₂O₆ • 2H₂O

Products

RéférenceConditionnement Qté
584223-25MG Flacon en verre 25 mg
Description
OverviewA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
Catalogue Number584223
Brand Family Calbiochem®
Synonyms1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate, THU, H4U
References
ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
Riva, C., et al. 1992. Chemotherapy 38, 358.
Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
Product Information
CAS number18771-50-1
FormLiquid
FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
Hill FormulaC₉H₁₆N₂O₆ • 2H₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcytidine deaminase
Purity≥90% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
584223-25MG 04055977264999

Documentation

InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ Tetrahydrouridine - CAS 18771-50-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
584223

Références bibliographiques

Aperçu de la référence bibliographique
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
Riva, C., et al. 1992. Chemotherapy 38, 358.
Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-January-2019 JSW
Synonyms1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate, THU, H4U
DescriptionA potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
FormLiquid
FormulationA 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number18771-50-1
Structure formulaStructure formula
Purity≥90% by TLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Standard Handling
ReferencesYusa, K., et al. 1995. Biochem. Biophys. Res. Commun. 206, 486.
Bouffard, D.Y., et al. 1993. Biochem Pharmacol. 45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol. 30, 7.
Riva, C., et al. 1992. Chemotherapy 38, 358.
Yusa, K., et al. 1992. J. Biol. Chem. 267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc. 89, 6720.