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555552 InSolution™ Rho Kinase Inhibitor - Calbiochem

The InSolution™ Rho Kinase Inhibitor controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: ROCK
555552
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₆H₂₁N₃O₂S • 2HCl

Products

RéférenceConditionnement Qté
555552-500UG Ampoule plast. 500 μg
Description
Catalogue Number555552
Brand Family Calbiochem®
References
ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
Product Information
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Hill FormulaC₁₆H₂₁N₃O₂S • 2HCl
Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetROCK
Primary Target K<sub>i</sub>1.6 nM against Rho-associated kinase (ROCK)
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
555552-500UG 04055977268423

Documentation

InSolution™ Rho Kinase Inhibitor - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ Rho Kinase Inhibitor - Calbiochem Certificats d'analyse

TitreNuméro de lot
555552

Références bibliographiques

Aperçu de la référence bibliographique
Ikenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-September-2008 RFH
DescriptionA cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; Ki = 1.6 nM). Inhibits other serine/threonine kinases only at higher concentrations (Ki = 630 nM for PKA, 9.27 µM for PKC, and 10.1 µM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in NT-2 cells (IC50 = 2.5 µM). Reported to be a more potent and selective inhibitor than Y-27632 (Cat. No. 688000 & 688001).
FormLiquid
FormulationA 10 mM (500 µg/128 µl) solution of Rho Kinase Inhibitor (Cat. No. 555550) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₁₆H₂₁N₃O₂S • 2HCl
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Harmful
ReferencesIkenoya, M., et al. 2002. J. Neurochem. 81, 9.
Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.