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553590 InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem

A cell-permeable polyketide that displays potent antitumor properties in eukaryotes.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II

Primary Target: nuclear export of LR-NES
553590
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
163564-92-9C₂₈H₄₀O₅

Products

RéférenceConditionnement Qté
553590-2UG Ampoule plast. 2 μg
Description
OverviewA cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.
Catalogue Number553590
Brand Family Calbiochem®
SynonymsRatjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
References
ReferencesKöster, M., et al. 2003. Exp. Cell Res. 286, 321.
Kalesse, M., et al. 2001. Chem biochem 2, 709.
Gerth, K., et al. 1995. J. Antibiot. 48, 973.
Product Information
CAS number163564-92-9
ATP CompetitiveN
FormLiquid
FormulationA 5 µg/ml solution (2 µg in 400 µl) in methanol.
Hill FormulaC₂₈H₄₀O₅
Chemical formulaC₂₈H₄₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetnuclear export of LR-NES
Primary Target IC<sub>50</sub>≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
553590-2UG 04055977193763

Documentation

InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem Certificats d'analyse

TitreNuméro de lot
553590

Références bibliographiques

Aperçu de la référence bibliographique
Köster, M., et al. 2003. Exp. Cell Res. 286, 321.
Kalesse, M., et al. 2001. Chem biochem 2, 709.
Gerth, K., et al. 1995. J. Antibiot. 48, 973.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-September-2008 RFH
SynonymsRatjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
DescriptionA cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.
FormLiquid
FormulationA 5 µg/ml solution (2 µg in 400 µl) in methanol.
Intert gas (Yes/No) Packaged under inert gas
CAS number163564-92-9
Chemical formulaC₂₈H₄₀O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityMethanol (20 mg/ml) or aqueous buffers (≤100 µM)
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Flammable
ReferencesKöster, M., et al. 2003. Exp. Cell Res. 286, 321.
Kalesse, M., et al. 2001. Chem biochem 2, 709.
Gerth, K., et al. 1995. J. Antibiot. 48, 973.