527451 Sigma-AldrichInSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem
The InSolution™ PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ PKR Inhibitor, also referenced under CAS 608512-97-6, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 608512-97-6 | C₁₃H₈N₄OS |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 527451-5MG | Flacon en verre | 5 mg |
| Description | |
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| Overview | An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). The solid form of this compound (Cat. No. 527450) is also available. |
| Catalogue Number | 527451 |
| Brand Family | Calbiochem® |
| Synonyms | C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I |
| References | |
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| References | Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
| Product Information | |
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| CAS number | 608512-97-6 |
| Form | Liquid |
| Formulation | A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO. |
| Hill Formula | C₁₃H₈N₄OS |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | PKR |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 527451-5MG | 04055977270372 |
Documentation
InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem FDS
| Titre |
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InSolution™ PKR Inhibitor - CAS 608512-97-6 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 527451 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Zhu, P.J., et al. 2011. Cell 147, 1384. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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