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528101 InSolution™ PI-103

InSolution™ PI-103 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: mTOR Inhibitor V, PI 3-K Inhibitor V

528101
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₉H₁₆N₄O₃

Products

RéférenceConditionnement Qté
528101-2MG Ampoule plast. 2 mg
Description
Catalogue Number528101
Brand Family Calbiochem®
SynonymsmTOR Inhibitor V, PI 3-K Inhibitor V
References
ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
Knight, Z.A., et al. 2006. Cell 125, 733.
Product Information
FormLiquid
FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
Hill FormulaC₁₉H₁₆N₄O₃
Chemical formulaC₁₉H₁₆N₄O₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
528101-2MG 04055977270471

Documentation

InSolution™ PI-103 FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ PI-103 Certificats d'analyse

TitreNuméro de lot
528101

Références bibliographiques

Aperçu de la référence bibliographique
Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
Knight, Z.A., et al. 2006. Cell 125, 733.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-December-2008 JSW
SynonymsmTOR Inhibitor V, PI 3-K Inhibitor V
DescriptionA cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo.
FormLiquid
FormulationA 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528100) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₉H₁₆N₄O₃
Structure formulaStructure formula
Purity≥97% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesRaynaud, F.I., et al. 2007. Cancer Res. 67, 5840.
Fan, Q.W., et al. 2006. Cancer Cell 9, 341.
Knight, Z.A., et al. 2006. Cell 125, 733.