487929 Sigma-AldrichInSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.
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Synonymes: Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 31430-18-9 | C₁₄H₁₁N₃O₃S |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 487929-10MG | Flacon en verre | 10 mg |
| Description | |
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| Overview | Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM). The solid form of this compound (Cat. No. 487928) is also available. |
| Catalogue Number | 487929 |
| Brand Family | Calbiochem® |
| Synonyms | Methyl-(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamate, Methyl-5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate, R17934 |
| Product Information | |
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| CAS number | 31430-18-9 |
| Form | Liquid |
| Formulation | A 50 mM (10 mg/664 µL) solution of Nocodazole (Cat. No. 487928) in DMSO. |
| Hill Formula | C₁₄H₁₁N₃O₃S |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Microtubules |
| Secondary target | Certain kinases |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 487929-10MG | 04055977200393 |
Documentation
InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem FDS
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InSolution™ Nocodazole - CAS 31430-18-9 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 487929 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Park, H., et al. 2012. Chem. Med. Chem. 7, 53. Bunz, F., et al. 1998. Science 282, 1497. Fleischman, L.F., et al. 1993. Oncogene 8, 771. Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429. Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239. Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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