Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

474788 InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem

Potent, reversible, and cell-permeable proteasome inhibitor. Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Proteasome Inhibitor XI

474788
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₆H₄₁N₃O₅

Products

RéférenceConditionnement Qté
474788-10MG Flacon en verre 10 mg
Description
OverviewPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
Catalogue Number474788
Brand Family Calbiochem®
SynonymsProteasome Inhibitor XI
Application Data
References
ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.
Product Information
FormLiquid
FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
Hill FormulaC₂₆H₄₁N₃O₅
Chemical formulaC₂₆H₄₁N₃O₅
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Target K<sub>i</sub>Ki = 4 nM for proteasomal inhibition
Secondary targetIKK
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Leu-Leu-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 11-22

Highly flammable.
Harmful if swallowed.
S PhraseS: 16-7

Keep away from sources of ignition - No Smoking.
Keep container tightly closed.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Flammable
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Protect from Light Protect from light
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
474788-10MG 04055977185461

Documentation

InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ MG-132 in EtOH, ≥95% by HPLC - Calbiochem Certificats d'analyse

TitreNuméro de lot
474788

Références bibliographiques

Aperçu de la référence bibliographique
Steinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-March-2012 JSW
SynonymsProteasome Inhibitor XI
Application Data
DescriptionPotent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) is also available.
FormLiquid
FormulationA 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₆H₄₁N₃O₅
Peptide SequenceZ-Leu-Leu-Leu-CHO
Purity≥95% by HPLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initital thaw, aliquot and freeze (-70°C).
Toxicity Flammable
ReferencesSteinhilb, M.L., et al. 2001. J. Biol. Chem. 276, 4476.
Meriin, A.B., et al. 1998. J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996. Ann. Rep. Med. Chem. 31, 279.
Klafki, H.W., et al. 1996. J. Biol. Chem. 271, 2865.
Lee, D.H., and Goldberg, A.L., 1996. J. Biol. Chem. 271, 27280.
Wiertz, E.J., et al. 1996. Cell 84, 769.
Jensen, T.J., et al. 1995. Cell 83, 129.
Read, M.A., et al. 1995. Immunity 2, 493.
Rock, K.L., et al. 1994. Cell 78, 761.