407602 Sigma-AldrichInSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem
The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps.
More>> The Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor controls the activity of Interleukin-1 Receptor-Associated-Kinase-1/4. Primarily used for Phosphorylation & Dephosphorylation apps. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 509093-47-4 | C₂₀H₂₁N₅O₄ |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 407602-5MG | Flacon en verre | 5 mg |
| Description | |
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| Overview | A cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available. |
| Catalogue Number | 407602 |
| Brand Family | Calbiochem® |
| Synonyms | N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide, N-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole |
| Product Information | |
|---|---|
| CAS number | 509093-47-4 |
| Form | Liquid |
| Formulation | A 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO. |
| Hill Formula | C₂₀H₂₁N₅O₄ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | IRAK-1/4 |
| Primary Target IC<sub>50</sub> | 300 nM and 200 nM for IRAK-1 and -4 |
| Purity | ≥98% by HPLC |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 407602-5MG | 04055977211306 |
Documentation
InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem FDS
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InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 407602 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Srivastava, R., et al. 2012. Cancer Res. 72, In press. Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429. Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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