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401485 InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem

The InSolution™ IKK-2 Inhibitor, SC-514 controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: IKK-2
401485
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₉H₈N₂OS₂

Products

RéférenceConditionnement Qté
401485-1MG Ampoule plast. 1 mg
Description
Catalogue Number401485
Brand Family Calbiochem®
References
ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
Product Information
ATP CompetitiveY
FormClear to pale yellow Liquid
FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Hill FormulaC₉H₈N₂OS₂
Chemical formulaC₉H₈N₂OS₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
401485-1MG 04055977212006

Documentation

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

InSolution™ IKK-2 Inhibitor, SC-514 - Calbiochem Certificats d'analyse

TitreNuméro de lot
401485

Références bibliographiques

Aperçu de la référence bibliographique
Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
FormClear to pale yellow Liquid
FormulationA 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401479) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₉H₈N₂OS₂
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Irritant
ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.