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14-926M IKKε Protein, active, 250 µg

Active, N-terminal FLAG & GST-tagged, recombinant, human IKKε, full length. For use in Kinase Assays.

IKKε Protein, active, 250 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
14-926M
250 µg  Also available in 10μg size as catalog # 14-926 and in bulk as catalog # 14-926-K.
Purchase on Sigma-Aldrich

Aperçu

Replacement Information
Description
Catalogue Number14-926M
Trade Name
  • Upstate
DescriptionIKKε Protein, active, 250 µg
OverviewIKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
References
Product Information
Presentation50mM Tris/HCl pH7.5, 150mM NaCl, 10mM β-glycerophosphate, 1mM sodium orthovanadate, 1mM NaF, 28% v/v glycerol, 0.03% Brij-35, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol
Quality LevelMQ300
Applications
ApplicationActive, N-terminal FLAG & GST-tagged, recombinant, human IKKε, full length. For use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
SourceN-terminal FLAG and GST-tagged, recombinant, human IKK full length, expressed by baculovirus in Sf21 insect cells.
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Gene Symbol
  • IKBKE
  • IKKe
  • IKKI
  • KIAA0151
Protein TargetIKKe
Purification MethodPurified by immunoaffinity chromatography.
Target Sub-FamilyMisc
UniProt Number
Molecular Weight109 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of casein.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10μg size as catalog # 14-926 and in bulk as catalog # 14-926-K.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
14-926M 04053252851452

Produits & Applications associés

Alternative Packsize

Référence Description
14-926 IKKε Protein, active, 10 µg

Familles de produits

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Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Catégories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases