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401482 IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem

The IKK-2 Inhibitor V, also referenced under CAS 978-62-1, controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354

Primary Target: IKK-2
401482
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
978-62-1C₁₅H₈ClF₆NO₂

Products

RéférenceConditionnement Qté
401482-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable salicylamide compound that acts as an IKK-2 inhibitor by selectively blocking IκBα phosphorylation (IC50 ~ 250 nM) and thereby prevents the induction of NF-κB p65 nuclear translocation. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 < 1 µM) in cardiomyocytes, and ameliorate insulin resistance in KKAy mice by regulating adiponectin release.
Catalogue Number401482
Brand Family Calbiochem®
SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
References
ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
Tanaka, A., et al. 2004. Blood 105, 2324.
Product Information
CAS number978-62-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₈ClF₆NO₂
Chemical formulaC₁₅H₈ClF₆NO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>~ 250 nM blocking IκBα phosphorylation
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
401482-5MG 04055977211979

Documentation

IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
401482

Références bibliographiques

Aperçu de la référence bibliographique
Kamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
Tanaka, A., et al. 2004. Blood 105, 2324.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2008 JSW
SynonymsN-(3,5-Bis-trifluoromethylphenyl)-5-chloro-2-hydroxybenzamide, IMD-0354
DescriptionA cell-permeable IKK-2 inhibitor that selectively blocks IκBα phosphorylation (IC50 ~250 nM) and prevents the induction of NF-κB p65 nuclear translocation. Reported to suppress neoplastic proliferation of mast cells with constitutively activated c-kit receptor. Shown to offer cardioprotection by reducing IL-1β and MCP-1 production (IC50 <1 µM) in cardiomyocytes, and ameliorate insulin resistance in diabetic KKAy mice by regulating adiponectin release.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number978-62-1
Chemical formulaC₁₅H₈ClF₆NO₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKamon, J., et al. 2004. Biochem. Biophys. Res. Commun. 323, 242.
Onai, Y., et al. 2004. Cardiovasc. Res. 63, 51.
Tanaka, A., et al. 2004. Blood 105, 2324.