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401479 IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

401479
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Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
354812-17-2C₉H₈N₂OS₂

Products

RéférenceConditionnement Qté
401479-1MG Ampoule plast. 1 mg
Description
OverviewA cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
Catalogue Number401479
Brand Family Calbiochem®
SynonymsSC-514
References
ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
Product Information
CAS number354812-17-2
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₉H₈N₂OS₂
Chemical formulaC₉H₈N₂OS₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
401479-1MG 07790788055806