Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

538256 IDO Inhibitor - CAS 914471-09-3 - Calbiochem

A cell-potent, bioavailable, non-toxic hydroxyamidine that acts as a selective and D-trp competitive IDO inhibitor. Rapidly decreases cellular kynurenine levels & inhibits B16-GM-CSF melanoma tumor growth.

IDO Inhibitor - CAS 914471-09-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor

Primary Target: IDO
538256
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
914471-09-3C₉H₇ClFN₅O₂

Products

RéférenceConditionnement Qté
5382560001 Flacon en verre 10 mg
Description
OverviewA cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 > 10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2 < 0.5 h).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538256
Brand Family Calbiochem®
Synonyms4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor
DescriptionIDO Inhibitor
References
ReferencesYue, E.W., et al. 2009. J. Med. Chem. 52, 7364.
Product Information
CAS number914471-09-3
FormOff-white powder
Hill FormulaC₉H₇ClFN₅O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetIDO
Primary Target IC<sub>50</sub>67 nM for hIDO
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
5382560001 04054839059513

Documentation

IDO Inhibitor - CAS 914471-09-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

IDO Inhibitor - CAS 914471-09-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
538256

Références bibliographiques

Aperçu de la référence bibliographique
Yue, E.W., et al. 2009. J. Med. Chem. 52, 7364.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-June-2016 JSW
Synonyms4-Amino-N-(3-chloro-4-fluorophenyl)-Nʹ-hydroxy-1,2,5-oxadiazole-3-carboximidamide, IDOi, Indoleamine 2,3-Dioxygenase Inhibitor
DescriptionA cell-permeable, bioactive, non-toxic oxadiazolohydroxyamidine based compound that acts as a potent, selective and competitive inhibitor of indoleamine 2,3-dioxygenase (IDO; IC50 = 67 nM for hIDO). Reversibly binds to the catalytically active heme iron (Fe2+) and is inactive towards closely related tryptophan 2,3-dioxygenase (TDO; IC50 > 10 µM). Shown to dose-dependently decrease kynurenine levels (IC50 = 19 & 46 nM in HeLa treated with IFN-γ & B16-GM-CSF melanoma cells, respectively) and suppress B16-GM-CSF xenograft tumor growth in C57BL/6 mice (75 mg/kg, s.c., b.i.d.). Though orally bioavailable, but undergoes a rapid clearance (t1/2 < 0.5 h).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number914471-09-3
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYue, E.W., et al. 2009. J. Med. Chem. 52, 7364.