Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

382175 Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem

The Histone Deacetylase Inhibitor VIII, also referenced under CAS 1045792-66-2, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: HDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid

382175
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1045792-66-2C₂₂H₃₀N₄O₆

Products

RéférenceConditionnement Qté
382175-1MG 1 mg
Description
OverviewA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
Catalogue Number382175
Brand Family Calbiochem®
SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
References
ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
Product Information
CAS number1045792-66-2
FormBeige to light brown solid
Hill FormulaC₂₂H₃₀N₄O₆
Chemical formulaC₂₂H₃₀N₄O₆
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
382175-1MG 04055977212808

Documentation

Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
382175

Références bibliographiques

Aperçu de la référence bibliographique
Kozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-November-2010 JSW
SynonymsHDAC Inhibitor VIII, N-(4-(3-(((7-Hydroxyamino-7-oxoheptyl)amino)carbonyl)-5-isoxazolyl)phenyl)-1,1-dimethylethylester, carbamic acid
DescriptionA cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50 <1.0 µM).
FormBeige to light brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1045792-66-2
Chemical formulaC₂₂H₃₀N₄O₆
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKozikowski, A.P., et al. 2008. J. Med. Chem. 51, 4370.