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382172 Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem

The Histone Deacetylase Inhibitor VI, HNHA, also referenced under CAS 926908-04-5, controls the biological activity of Histone Deacetylase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-Hydroxy-7-(2-naphthylthio)heptanomide

382172
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
926908-04-5C₁₇H₂₁NO₂S

Products

RéférenceConditionnement Qté
382172-10MG Ampoule plast. 10 mg
Description
OverviewA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
Catalogue Number382172
Brand Family Calbiochem®
SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
References
ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.
Product Information
CAS number926908-04-5
FormWhite solid
Hill FormulaC₁₇H₂₁NO₂S
Chemical formulaC₁₇H₂₁NO₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
382172-10MG 04055977212785

Documentation

Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Histone Deacetylase Inhibitor VI, HNHA - CAS 926908-04-5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
382172

Références bibliographiques

Aperçu de la référence bibliographique
Kim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.

Informations techniques

Titre
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsN-Hydroxy-7-(2-naphthylthio)heptanomide
DescriptionA cell-permeable hydroxyamide-based SAHA analog that potently inhibits histone deacetylase (HDAC) activity (IC50 = 100 nM). Shown to induce histone acetylation and p21 transcription with concomitent inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. Reported to be more potent than SAHA in inhibiting tumor growth in a murine xenograph model in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number926908-04-5
Chemical formulaC₁₇H₂₁NO₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesKim, D.H., et al. 2007. Biochem. Biophys. Res. Commun. 356, 233.