Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

3779 Histamine, Free Base - CAS 51-45-6 - Calbiochem

A potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(4-Imidazolyl)ethylamine

3779
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
51-45-6C₅H₉N₃

Products

RéférenceConditionnement Qté
3779-1GM Flacon en verre 1 gm
Description
OverviewA potent vasodilator found in normal tissues and blood. Activates nitric oxide synthase. Formed by the decarboxylation of L-histidine. Activation of histamine H1 receptors leads to Ca2+ mobilization, whereas histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Stimulated time- and concentration-dependent increase in p38 and p42/p44 MAP kinases in DDT(1) MF2 cells.
Catalogue Number3779
Brand Family Calbiochem®
Synonyms2-(4-Imidazolyl)ethylamine
References
ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
Product Information
CAS number51-45-6
FormWhite solid
Hill FormulaC₅H₉N₃
Chemical formulaC₅H₉N₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMS1050000
Safety Information
R PhraseR: 22-36/37/38-42/43

Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation and skin contact.
S PhraseS: 26-36/37-22

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing and gloves.
Do not breathe dust.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
3779-1GM 07790788049744

Documentation

Histamine, Free Base - CAS 51-45-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Histamine, Free Base - CAS 51-45-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
3779

Références bibliographiques

Aperçu de la référence bibliographique
Robinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-June-2011 JSW
Synonyms2-(4-Imidazolyl)ethylamine
DescriptionA potent vasodilator found in normal tissues and blood. Formed by the decarboxylation of L-histidine. Activates nitric oxide synthase (NOS), resulting in the release of nitric oxide. Activation of histamine H1 receptors leads to Ca2+ mobilization; whereas, histamine H2 receptor activation stimulates adenylate cyclase activity in neurons. Inhibits the synthesis of IL-2 and γ-IFN in peripheral blood mononuclear cells and lipopolysaccharide-induced synthesis of TNF-α in monocytes via H2 receptor activation.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number51-45-6
RTECSMS1050000
Chemical formulaC₅H₉N₃
Structure formulaStructure formula
Purity≥97% by TLC
SolubilityH₂O (1 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 4719
ReferencesRobinson, A.J., and Dickerson, J.M. 2001. Br. J. Pharmacol. 133, 178.
Izumi, H., et al. 1995. Am. J. Obstet. Gynecol. 172, 1477.
Vannier, E., and Dinarello, C.A. 1994. J. Biol. Chem. 269, 9952.
Yan, Q.Z., et al. 1994. Agents Actions 41, C111.
Moncada, S., et al. 1991. Pharmacol. Rev. 43, 109.
Bloom, F.E. 1990. in Pharmacological Basis of Therapeutics p. 224 (Gilman, A.G., et al., Eds.) Pergamon Press, New York.