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376816 Hexokinase II VDAC Binding Domain Peptide, Cell-Permeable - Calbiochem

A cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: HXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂

Primary Target: Detach and translocate HXK2 from mitochondria to the cytosol
376816
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Aperçu

Tableau de caractéristiques principal

Empirical Formula
C₁₈₈H₂₉₁N₅₃O₄₀S₂

Products

RéférenceConditionnement Qté
376816-1MG Ampoule plast. 1 mg
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Description
OverviewA cell-permeable peptide analog of Hexokinase II VDAC binding domain peptide (Cat. No. 376815). The internalization domain of the Antennapedia homeoprotein is fused to the methionine amino terminal. Shown to completely detach and translocate HXK2 from mitochondria to the cytosol in HeLa cells at 100 µM. Does not induce Bax translocation or cytochrome c release when used alone. However, it markedly sensitizes cells to cytochrome c release and to the induction of apoptosis when used in combination with a Bax-dependent apoptosis inducer, Indomethacin (Cat. No. 405268).
Catalogue Number376816
Brand Family Calbiochem®
SynonymsHXK2VBD-cpm, H-RQIKIWFQNRRMKWKK-MIASHLLAYFFTELN-NH₂
References
ReferencesPastorino, J.G., et al. 2002. J. Biol. Chem. 277, 7610.
Holinger, E.P., et al. 1999. J. Biol. Chem. 274, 13298.
Sui, D., and Wilson, J.E. 1997. Arch. Biochem. Biophys. 345, 111.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
Chemical formulaC₁₈₈H₂₉₁N₅₃O₄₀S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetDetach and translocate HXK2 from mitochondria to the cytosol
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceH-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Met-Ile-Ala-Ser-His-Leu-Leu-Ala-Tyr-Phe-Phe-Thr-Glu-Leu-Asn-NH₂
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Référence GTIN
376816-1MG 04055977212976