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397100 HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem

A cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases.

HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Hydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II

Primary Target: tyrosine kinase
397100
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
120944-03-8C₂₀H₂₃O₁₀P

Products

RéférenceConditionnement Qté
397100-5MG Ampoule plast. 5 mg
Description
OverviewA cell-permeable analog of HNMPA that yields the parent compound upon cleavage by cytosolic esterases. Inhibits insulin receptor tyrosine kinase (IC50 = 100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM).
Catalogue Number397100
Brand Family Calbiochem®
SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
References
ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
Saperstein, R., et al. 1989. Biochemistry 28, 5694.
Product Information
CAS number120944-03-8
ATP CompetitiveN
FormColorless oil
Hill FormulaC₂₀H₂₃O₁₀P
Chemical formulaC₂₀H₂₃O₁₀P
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targettyrosine kinase
Primary Target IC<sub>50</sub>100 µM and 10 µM against insulin receptor tyrosine kinase and insulin-stimulated glucose oxidation in isolated rat adipocytes, respectively
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
397100-5MG 04055977212549

Documentation

HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

HNMPA-(AM)₃ - CAS 120944-03-8 - Calbiochem Certificats d'analyse

TitreNuméro de lot
397100

Références bibliographiques

Aperçu de la référence bibliographique
Baltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
Saperstein, R., et al. 1989. Biochemistry 28, 5694.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsHydroxy-2-naphthalenylmethylphosphonic Acid Trisacetoxymethyl Ester, Pro-drug II
DescriptionA cell-permeable analog of HNMPA. Inhibits insulin receptor tyrosine kinase (IC50 = 100 mM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50 = 10 µM). Also reported to inhibit tyrosine autophosphorylation of the human insulin receptor (IC50 = 200 µM). It has no effect on PKA (at concentrations up to 1 mM) or PKC (at concentrations up to 420 µM).
FormColorless oil
CAS number120944-03-8
Chemical formulaC₂₀H₂₃O₁₀P
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBaltensperger, K., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 7885.
Saperstein, R., et al. 1989. Biochemistry 28, 5694.