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400084 HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Adaptaquin

400084
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
385786-48-1C₂₁H₁₆ClN₃O₂

Products

RéférenceConditionnement Qté
400084-10MG Flacon en verre 10 mg
Description
OverviewA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
Catalogue Number400084
Brand Family Calbiochem®
SynonymsAdaptaquin
References
ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
Product Information
CAS number385786-48-1
FormTan solid
Hill FormulaC₂₁H₁₆ClN₃O₂
Chemical formulaC₂₁H₁₆ClN₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
400084-10MG 04055977212327

Documentation

HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem Certificats d'analyse

TitreNuméro de lot
400084

Références bibliographiques

Aperçu de la référence bibliographique
Smirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-April-2022 JSW
SynonymsAdaptaquin
DescriptionA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
FormTan solid
CAS number385786-48-1
Chemical formulaC₂₁H₁₆ClN₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.