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400086 HIF Inhibitor VI - Calbiochem

The HIF-1 Inhibitor, NSC-134754 controls the biological activity of HIF-1. This small molecule/inhibitor is primarily used for Cell Structure applications.

HIF Inhibitor VI - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC-134754

400086
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₇H₃₄N₂O₂

Products

RéférenceConditionnement Qté
400086-5MG Flacon en verre 5 mg
Description
OverviewA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
Catalogue Number400086
Brand Family Calbiochem®
SynonymsNSC-134754
References
ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.
Product Information
FormBrown solid
Hill FormulaC₂₇H₃₄N₂O₂
Chemical formulaC₂₇H₃₄N₂O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
400086-5MG 04055977212334

Documentation

HIF Inhibitor VI - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

HIF Inhibitor VI - Calbiochem Certificats d'analyse

TitreNuméro de lot
400086

Références bibliographiques

Aperçu de la référence bibliographique
Chau, N.M., et al. 2005. Cancer Res. 65, 4918.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2013 JSW
SynonymsNSC-134754
DescriptionA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₇H₃₄N₂O₂
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.