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371955 H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem

A broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl

Primary Target: MLCK
371955
Purchase on Sigma-Aldrich

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
108930-17-2C₁₄H₁₇N₃O₂S · 2HCl

Products

RéférenceConditionnement Qté
371955-1MG Ampoule plast. 1 mg
Description
OverviewA broad-based, cell-permeable, reversible, ATP-competitive serine/threonine kinase inhibitor. Inhibits protein kinase A (Ki = 3.0 µM), myosin light chain kinase (Ki = 97 µM), protein kinase C (Ki = 6.0 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
Catalogue Number371955
Brand Family Calbiochem®
Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
References
ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.
Product Information
CAS number108930-17-2
ATP CompetitiveY
FormLight yellow lyophilized solid
Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMLCK
Primary Target K<sub>i</sub>3.0 µM, 97 µM, 6.0 µM, 5.8 µM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
371955-1MG 04055977213485

Documentation

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem Certificats d'analyse

TitreNuméro de lot
371955

Références bibliographiques

Aperçu de la référence bibliographique
Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

Brochure

Titre
Caspases and other Apoptosis Related Tools Brochure
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-January-2010 RFH
Synonyms1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl
DescriptionA broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 µM), protein kinase A (Ki = 3.0 µM), protein kinase C (Ki = 6 µM), and protein kinase G (Ki = 5.8 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
FormLight yellow lyophilized solid
Intert gas (Yes/No) Packaged under inert gas
CAS number108930-17-2
Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityH₂O (20 mg/ml). Further dilute with aqueous buffers just prior to use.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Toxicity Standard Handling
ReferencesKu, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Bergstrand, H., et al. 1992. J. Pharmacol. Exp. Therap. 263, 1334.
Gimond, C., et al. 1992. Exp. Cell Res. 203, 365.
Quick, J., et al. 1992. Biochem. Biophys. Res. Commun. 187, 657.
Bouli, N.M., and Davis, M. 1990. Brain Res. 525, 198.
Takahashi, I., et al. 1990. J. Pharmacol. Exp. Ther. 255, 1218.
Schachtele, C., et al. 1988. Biochem. Biophys. Res. Commun. 151, 542.
Kawamoto, S., and Hidaka, H. 1984. Biochem. Biophys. Res. Commun. 125, 258.

Produits & Applications associés

Catégories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors