370679 Sigma-AldrichGuanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).
More>> A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 172806-20-1 | C₁₈H₁₄BrN₅O₆PS · Na |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 370679-1UMOL | Ampoule plast. | 1 umol |
| Description | |
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| Overview | A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg. |
| Catalogue Number | 370679 |
| Brand Family | Calbiochem® |
| Synonyms | Rp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI |
| References | |
|---|---|
| References | Wei, J.Y., et al. 1996. Biochemistry 35, 16815. Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110. |
| Product Information | |
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| CAS number | 172806-20-1 |
| ATP Competitive | N |
| Declaration | Sold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI. |
| Form | Lyophilized |
| Hill Formula | C₁₈H₁₄BrN₅O₆PS · Na |
| Chemical formula | C₁₈H₁₄BrN₅O₆PS · Na |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | PKG1α & 1β |
| Primary Target K<sub>i</sub> | 30 nM against PKG1α & 1β |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 370679-1UMOL | 04055977191714 |
Documentation
Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem FDS
| Titre |
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Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 370679 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Wei, J.Y., et al. 1996. Biochemistry 35, 16815. Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110. |